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Drug Information: Clomiphene (kloe' Mi Feen)
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How long will the treatment last? Most women will go through a maximum of three to six drug cycles: it can take a month or two of drug therapy to start ovulating regularly. If it doesn’t prove successful after six months, your doctor will probably start discussing other options with you. However, it is recommended that treatment can continue for up to 12 cycles, probably with a gap between courses of treatment, because there is more chance of ovulation starting if treatment is continued for this long. If you have polycystic ovary syndrome this treatment may not work for you, as 15 to 40 per cent of women with PCOS are resistant to clomifene (Beck et al 2005). This is more common in women who have a BMI (body mass index) greater than 25. In this case, your doctor may recommend that you try to lose some weight. Even a modest weight loss of about five per cent of your body weight can help improve your chances of ovulation. Your doctor may also prescribe metformin, an insulin-sensitising drug. Metformin can help you respond to clomifene and has been shown to increase the chances of ovulating and getting pregnant.
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